4-ACO-DMT: The Legal Synthetic Shroom Analogue that Canadians Can Find Online
4-ACO-DMT: The Legal Synthetic Shroom Analogue that Canadians Can Find Online

If you’re a shroom lover eager to explore the potential benefits of psilocybin, without dealing with dubious legal status, then 4-ACO-DMT is may be a legal alternative, at least in Canada. Often labelled as the “synthetic shroom”, this compound is gaining traction among aficionados looking for something new – and perhaps more importantly – something that’s convenient and legal to buy online.

What is 4-AcO-DMT?

4-AcO-DMT, a tryptamine semi-synthetic research chemical also known as O-acetylpsilocin, psilacetin or “synthetic mushrooms” could hold the key to what Albert Hofmann, the chemist famously credited with discovering LSD, had his sights set on in the early ’60s. Developed in collaboration with Franz Troxler under the umbrella of pharmaceutical giant Sandoz, what began as Hofmann and Troxler’s experiments with compounds similar to psilocin eventually birthed what we now know as 4-AcO-DMT. Put simply, the relationship between 4-AcO and its psilocybin mushroom siblings is no placebo; analysis suggests that, similar to psilocybin, 4-AcO-DMT too breaks down into psilocin in the body during first pass metabolism. With an illustrious history such as that preceding it, one thing’s certain: whether this substance dazzles us or falls short of our expectations, it will certainly remain embedded firmly in scientific history.

Chemical Structure

Nowadays, 4-ACO-DMT is quickly attracting attention – both from the scientific and recreational communities. This trendy tryptamine compound is what’s known as an “acetylated analog” of psilocin. The chemical is sold on the research chemical market, mainly as a way to explore its potential therapeutic properties in a safe setting.

The chemical structures of psilacetin, psilocybin, and serotonin.

Psilacetin, a structural analog of the popular psychedelic compound psilocybin, is alternatively known as 4-AcO-DMT, O-Acetylpsilocin, 4-Acetoxy-DMT and 4 Acetoxy N.N dimethyltryptamine. It should be noted that while chemically similar to its predecessor psilocybin due to their shared serotonin neurotransmitter base; they differ in terms of structure:  Psilocin being an acetylated derivative of psilocybin which has been phosphorylated instead.

Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice | ACS Publications

Although we don’t fully understand the metabolic process that 4-AcO-DMT undergoes in humans, it is likely its deacetylation to form psilocin. Once this occurs, available evidence suggests that psilocin binds with serotonin 5-HT2A receptors, inducing a psychedelic experience. By drawing from previous research on tryptamine compounds and their metabolism alike, we can begin to make more informed conclusions about how human bodies interact with these types of psychedelics.

Smart chemists also see it as a way to have their own mind-expanding quest without hunting down wild magic mushrooms – an enterprise becoming more difficult as use of this drug becomes more popular.

All in all, 4-ACO-DMT appears to be a winning legal combination for thrill seekers and scientists alike!

What are the differences between magic mushrooms and 4-AcO-DMT?

What are the differences between magic mushrooms and 4-AcO-DMT?
Magic mushrooms vs. 4-AcO-DMT

Magic mushrooms and 4-AcO-DMT are both psychedelics, but they have some notable differences. While shrooms contain the psychoactive compound psilocybin, 4-AcO-DMT is a synthetic chemical that replicates the effects of psilocybin. Shrooms contain psychoactive compounds beyond psilocybin, which culminates in an overall psychedelic experience. Ingesting them is entirely different than taking pure psilocybin. These other chemicals, such as baeocystin, norbaeocystin, norpsilocin and aeruginascin all work together to produce their powerful effects.

More notable differences between the two psychedelics include:

Faster Onset time

While magic mushrooms can take up to an hour to take effect, 4-acO-DMT kicks in quickly. Reports indicate that the psychoactive properties of this substance become apparent as soon as inhalation occurs since they bypass first-pass metabolism in stomach and liver alike.


Those who take 4-AcO-DMT report a more consistent high, whereas taking magic mushrooms can be more unpredictable. Geiger et al. detailed in a 2018 review article that 4-AcO-DMT appears to create an experience with deeper colors, greater feelings of relaxation, warmth and euphoria than mushrooms containing psilocybin.

Duration of effect

User reports of differences between magic mushrooms and 4-AcO-DMT vary, with some experiencing a longer lasting effect from 4-AcO-DMT and others reporting that it has a much shorter duration.


The comedown period following a 4-AcO-DMT trip is said to be much gentler on the body than that of magic mushrooms.

Nausea effects

Users describe less nausea and body load with 4-AcO-DMT than with psilocybin, further contributing to its appeal.

Visual Effects

Users report that the visual effects of 4-AcO-DMT can often be more similar to those experienced on DMT on higher doses than psilocin or psilocybin. While anecdotal evidence seems to indicate there is a difference in effects between these compounds, there have yet to be any clinical studies exploring this difference.

Trip experience

If you’re looking for a more peaceful and calming experience, 4-AcO-DMT is the way to go. Is is reported that 4-AcO-DMT can provide euphoric feelings, warmth in your body, and vivid colors that will tantalize your senses while reducing the chances of a scary trip.

How can 4-ACO-DMT be ingested?

It seems that, with the abundance of psychedelic substances floating around these days, knowing how to take 4-ACO-DMT correctly is becoming more and more important. Many people are drawn to how fast acting and how “clean” this product is.

You have the choice of two methods to use 4-AcO-DMT: orally or intranasally, in microdoses or higher dosages for an enhanced effect. However, it’s important to note that both methods require different dosages. Currently, psilacetin is available as a brown or off-white powder (fumarate salt).

4-AcO-DMT: orally or intranasally, in microdoses or higher dosages for an enhanced effect.
4-AcO-DMT can be taken orally or intranasally, in microdoses or higher dosages for an enhanced effect.

The dosage and potency of the drug will vary depending on how hard one wishes to trip – with some noting that 4-AcO-DMT has its own psychedelic properties between those similar to mushrooms and DMT effects at different milligram amounts.

The most important thing to bear in mind when taking 4-ACO-DMT is to start with a low dosage; this will allow you to assess how the product affects you and how easily it takes effect. Moderation is key when it comes to psychedelics – so make sure you get your dosage just right!

Can you microdose 4-AcO-DMT?

The answer to this complex quandary may leave some up in the air, as it depends on your individual circumstances and preparations for microdosing. Generally speaking, the answer is yes – it is possible to partake in a responsible microdosing routine using 4-Aco-DMT.

4-AcO-DMT microdoses marketed online | Image: Neurodose

With no laws prohibiting or regulating the sale of 4-AcO-DMT, Canadian vendors have become a go-to source in purchasing the substance online. This is primarily why Canada has emerged as a hub for retailers specializing in this drug.

However, we urge all aspiring psychonauts to arm themselves with knowledge before engaging with any psychedelic substance. By researching proper safety protocols, monitoring psychoactive effects, and dialing into relevant dosage amounts, one can ensure they’re taking the correct approach towards their personal path of exploration.

Oral Ingestion

Taking 4-AcO-DMT orally can be a straightforward and secure solution, but first you must determine which ingestion method is right for you. Purchasing premeasured doses in pill form may be the most suitable option; however, other alternatives exist such as consuming it as a powder with water or your favorite beverage, encapsulating measured amounts of powder into capsules, or parachuting via cigarette paper. Regardless of what approach you take to ingesting 4-AcO-DMT orally, rest assured that there are multiple safe means of doing so.

The suggested dosage for oral consumption is as follows:

– Microdose: 2.5-5 mg

– Low dose: 5-10 mg

– Moderate dose: 10-20 mg

– High dose: 20-40 mg

– Heroic dose: 40 mg +

If you’re a novice to psychedelics, it is best that you start with an initial low-to-moderate dosage of 15 – 20 mg. This will give you the same effects and sensations as 3.5 g of magic mushrooms would, allowing for familiarity before transitioning into more intense experiences.

Intranasal Ingestion.

When inhaling 4-AcO-DMT powder through the nose, one experiences a stronger yet shorter effect. One should be wary though because snorting it could cause some uncomfortable feelings or sensations. Therefore, you must take these potential side effects into account before determining your own dose size.

The recommended dosage for intranasal ingestion is as follows:

– Microdose: 2-4 mg

– Low dose: 4-7.5 mg

– Moderate dose: 7.5-15 mg

– High dose: 15-30 mg

– Heroic dose: 30 mg +

For safe and accurate dosing, a milligram scale is essential. If you’re considering using research chemicals, a scale is an invaluable asset to ensure harm reduction.

The potential benefits of using 4-AcO-DMT over psilocybin mushrooms

CaaMTech Solves Crystal Structure of Psilacetin |

It appears that 4-AcO-DMT is an economical choice for research due to its cost of synthesis, but why should the average person care?

The beauty lies in the simplicity– consuming 4-AcO-DMT is much easier to dose than participating in expensive clinical trials or attempting to cultivate psilocybin mushrooms on your own.

4-AcO-DMT offers an intriguing alternative for those seeking more control over their psychedelic journey. Unlike mushrooms, you can accurately measure out your desired dosage without the uncertainty of leaving it up to luck! So if precision and reliability are important factors when considering a psychedelic experience – 4-AcO-DMT is worth exploring further.

Does 4-AcO-DMT offer therapeutic effects similar to psilocybin?

Worthy of note, 4-AcO-DMT is a synthetic compound that doesn’t have the same chemical makeup as psilocybin; however, many users still find its effects to be comparable or even surpass those of magic mushrooms. It has been suggested by Dr. Nichols  that this drug may act as an alternative form of treatment for mental health issues such as depression due to it breaking down into psilocin – thus allowing people to experience profound and transformative trips without having any psychedelic compounds in their body post consumption.

At this time, potential therapeutic uses of psilacetin (4-AcO-DMT) are based on anecdotal evidence alone. As such, there can be numerous variations in terms of the environment in which it is taken, dosage amount and purity that need to be considered when assessing these reports.

Online retailers in Canada claim that 4-AcO-DMT microdoses can:

  • Boost Cognitive functioning
  • Increase productivity
  • Reduce stress & anxiety
  • Regulate mood (hypothalamic pituitary axis)
  • Help with ADHD
  • Increase creativity

Despite the structural resemblance between 4-AcO-DMT and psilocybin, there are still no reliable studies to validate this claim of a similar safety profile. Thus, it’s essential that we reiterate this fact one more time.

Is 4-AcO-DMT Safe?

While there is no denying that 4-AcO-DMT can lead to a pleasant experience, the lack of research and evidence makes it difficult to say whether or not it is actually safe.

Though there have been no official studies to verify it, many presume that 4-AcO-DMT has the same safety profile as mushrooms containing psilocybin. However, these are just assumptions and so far, no clinical data exists to support them.

Like most psychedelics, there are some side effects people need to be aware of. When taking higher doses, it is possible to experience disorientation, confusion and paranoia; however with the right set and setting, these effects can be alleviated. In fact many users advocate having a sober companion when consuming

The two most often reported adverse effects according to personal reports seem to be increased thirstiness coupled with frequent urination, and feeling cold or continuously shivering – no matter the environmental temperature.

4-ACO-DMT Tolerance

Through swift action, 4-ACO-DMT tolerance accumulates shortly after ingestion and lingers in the body for approximately a week. This build up affects other classic psychedelics as well; if taken within this duration of time, your experience could be much weaker than normal. Therefore, remember to keep track of days when dosing these compounds!

The laws surrounding 4-acetoxy-DMT differ around the world and remain in a murky legal area. This is because there are no international drug statutes, like those under UN Convention on Psychotropic Substances, that address this chemical directly.While it’s true that some countries, such as Portugal and Spain, have opted to decriminalize the possession of 4-AcO-DMT – don’t get your hopes up just yet. Although citizens may not face jail time for carrying this substance, hefty fines and confiscations are still a possibility in exchange for punishment. Nevertheless, this is an important stride towards progressive drug policy reform.

Legality in Canada

4-AcO-DMT is not considered a controlled substance or specifically forbidden under Canadian law, technically. This is why we’re seeing many online vendors selling microdoses.

Legality in the US

The legal status of 4-AcO-DMT in the United States is somewhat ambiguous. It does not appear on any list of controlled substances, meaning it has no official scheduling designation. O-Acetylpsilocin is accepted for use in laboratories or as a research chemical; however, it is an acetate ester of psilocin and therefore would be considered analogous to a Schedule I Controlled Substance under the Federal Analogue Act if sold for human consumption.

You may be subject to prosecution if found in possession of this off-white powder. This is because the Federal Analogue Act, a subsection of the Controlled Substances Act, punishes people for using any substance that imitates Schedule I or II drugs and deliberately consumed by humans. As psilacetin replicates psilocin – an illegal Schedule I drug – there are severe consequences for manufacturing or distributing it! To avoid running into trouble with law enforcement, be sure to stay on top keeping your powder safe and secure!

Legality in the United Kingdom

According to UK law, since this is an ester of psilocin, it is classified as a Class A drug under the Misuse of Drugs Act 1971. Not only is this drug prohibited by law, but it also carries the harshest drug crime sentences. If you’re looking at 4-AcO-DMT from a legal perspective, possession and supply might leave you facing some serious consequences. So unless there is an asterisk with *freebies for all*, don’t even try it.

Legality in Italy

The short answer is no; 4-AcO-DMT is an ester of a prohibited substance and is thus illegal in Italy. It’s a shame for free spirits hoping to explore the psychedelic boundaries with their guidance. Let’s hope that one day such practices can eventually be accepted, or at least tolerated. Until then, travelers should steer clear of bringing anything psychedelic into the country.

When it comes to is 4-AcO-DMT legal, the answer is simple in most countries: don’t count on it. The ester of psilocin is an outlaw among its ilk and is illegal in many countries – including Australia, New Zealand, Germany, Italy, Switzerland, Brazil and Turkey. So if you’ve been wondering whether or not it’s okay to use this psychedelic substance then is best to err on the side of caution…in most cases it appears that the law says no.

Here are some countries that have banned 4-AcO in some way:

  • Australia
  • Belgium
  • Brazil
  • Germany
  • Italy
  • New Zealand
  • Sweden
  • United Kingdom
  • United States

Disclaimer:  Psychedelic Spotlight does not condone the use of illegal substances. The purpose of this article is for educational and harm reduction purposes only. If you suffer from a medical or mental condition, please consult with your doctor before taking any substance.

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